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Welcome to the Landau Lab for Structural Biology and Small-molecule Design

Lab’s Date of Birth: September 2012

Group_Dec2013
From left to right: Mickal, Orly, Meytal, Sleman, Hadar, Einav, Dikla, Asher 

Revealing the molecular and atomic details of protein function and regulation is imperative when trying to develop drugs that will accurately intervene with cellular processes. Our lab focuses on the mechanistic details of regulation in proteins that are central to physiological and pathophysiological processes. We aim to unveil the relationship between ligand-binding, dynamics, activation and transduction of signals, and to manipulate these processes using allosteric small-molecule modulators. This calls for a multidisciplinary approach that involves structural characterization via x-ray crystallography and electron microscopy, bioinformatics and small-molecule design. This combination of tools will be exerted on flexible proteins with multilayered regulation that have been recalcitrant to mechanistic analysis, such as platelet surface receptors that are key players in homeostasis, immunology and cancer

Funding:

We are grateful for funding from the Marie Curie Reintegration Grant, the I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (I-CORE Center of Excellence in Integrated Structural Cell Biology), Eliyahu Pen research Fund, Mallat Family Research Fund, J. and A. Taub Biological Research, and Alon Fellowship.


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