Welcome to the Landau Lab
Lab’s Date of Birth: September 2012
Our lab is fascinated about the structural and functional diversity of microbial functional amyloids. Amyloids are proteins that self-assemble into highly ordered fibrils that are mostly known for their involvement in neurodegenerative diseases, yet numerous amyloids are functional and participate in dedicated physiological activities, for example as virulence determinants in microbes, thereby serving as important drug targets.
The Human LL-37(17-29) Antimicrobial Peptide Reveals a Functional Supramolecular Structure
Image Credit: Sharon Amlani
Engelberg and Landau. Nat Commun 11, 3894 (2020)
Structural similarity between amyloidogenic segments from enteric bacteria curli and human pathological amyloids open ways to new anti-biofilm agents.
Perov et. al. PLoS Pathog 15(8): e1007978; 2019
Phenol Soluble Modulins (PSMs) secreted by the pathogenic S. aureus demonstrate a vast structural diversity of amyloid like structures encoding their functional diversity.
Salinas et. al. Nature Communications 9(1):3512; 2018
Cross-α amyloid-like fibrils secreted by the golden bacterium S. aureus are toxic to human cells
Tayeb-Fligelman et al. Science 355(6327): 831-833; 2017
Group Picture 2019
Lab members: Eilon, Hanan, Itai, Itzik, Orli, Meytal, Nimrod, Nir, Peleg, and Roee
Group Picture 2018
From left to right: Itzik, Ofir, Orli, Itai, Meytal, Nimrod, Nir
Group Picture 2017
From left to right: Itzik, Sunny, Einav, Orli, Meytal, Nir, Michal, May (and Kiara)
Group Picture 2015
From left to right: Sergei, Yulia, Einav, Meytal, Orly, Michal, Asher
Current Funding:
We are grateful for funding from the Technion, Israel Ministry of Science, Technology and Space, Israel Science Foundation – Individual Research Grant, DIP – Deutsch-Israelische Projektkooperation, U.S.-Israel Binational Science Foundation (BSF), Henri Gutwirth Fund for the Promotion of Research and the Henry Taub Prize for Academic Excellence.
Past Funding:
We are grateful for funding from the Technion, University of Michigan – Israel Collaborative Research Grant, U.S.-Israel Binational Science Foundation (BSF), Marie Curie Reintegration Grant, the I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (I-CORE Center of Excellence in Integrated Structural Cell Biology), Umbrella Cooperation – When Life Sciences and Engineering Converge, Eliyahu Pen research Fund, Mallat Family Research Fund, J. and A. Taub Biological Research, and Alon Fellowship from the Israeli Council for Higher Education.