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Welcome to the Landau Lab

Lab’s Date of Birth: September 2012

Our lab is fascinated about the structural and functional diversity of microbial functional amyloids. Amyloids are proteins that self-assemble into highly ordered fibrils that are mostly known for their involvement in neurodegenerative diseases, yet numerous amyloids are functional and participate in dedicated physiological activities, for example as virulence determinants in microbes, thereby serving as important drug targets.

The Human LL-37(17-29) Antimicrobial Peptide Reveals a Functional Supramolecular Structure

Image Credit: Sharon Amlani

Engelberg and Landau. Nat Commun 11, 3894 (2020)

 

Structural similarity between amyloidogenic segments from enteric bacteria curli and human pathological amyloids open ways to new anti-biofilm agents.

Results from CsgA publication
Perov et. al. PLoS Pathog 15(8): e1007978; 2019

 

Phenol Soluble Modulins (PSMs) secreted by the pathogenic S. aureus demonstrate a vast structural diversity of amyloid like structures encoding their functional diversity.

Extreme Amyloid Polymorphism in Staphylococcus aureus Virulent PSMα PeptidesSalinas et. al. Nature Communications 9(1):3512; 2018

 

Cross-α amyloid-like fibrils secreted by the golden bacterium S. aureus are toxic to human cells

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Tayeb-Fligelman et al. Science 355(6327): 831-833; 2017

 

 

Group Picture 2019

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Lab members: Eilon, Hanan, Itai, Itzik, Orli, Meytal, Nimrod, Nir, Peleg, and Roee

Group Picture 2018

From left to right: Itzik, Ofir, Orli, Itai, Meytal, Nimrod, Nir

Group Picture 2017
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From left to right: Itzik, Sunny, Einav, Orli, Meytal, Nir, Michal, May (and Kiara)

Group Picture 2015
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From left to right: Sergei, Yulia, Einav, Meytal, Orly, Michal, Asher

Current Funding:

We are grateful for funding from the Technion, Israel Ministry of Science, Technology and Space, Israel Science Foundation – Individual Research Grant, DIP – Deutsch-Israelische Projektkooperation, U.S.-Israel Binational Science Foundation (BSF), Henri Gutwirth Fund for the Promotion of Research and the Henry Taub Prize for Academic Excellence.

Past Funding:

We are grateful for funding from the Technion, University of Michigan – Israel Collaborative Research Grant, U.S.-Israel Binational Science Foundation (BSF), Marie Curie Reintegration Grant, the I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (I-CORE Center of Excellence in Integrated Structural Cell Biology), Umbrella Cooperation – When Life Sciences and Engineering Converge, Eliyahu Pen research Fund, Mallat Family Research Fund, J. and A. Taub Biological Research, and Alon Fellowship from the Israeli Council for Higher Education.